These changes should be made cautiously and under medical supervision. Increase monitoring with changes to: insulin dose, co-administered glucose lowering medications, meal pattern, physical activity; and in patients with hypoglycemia unawareness or renal or hepatic impairment Accidental mix-ups between basal insulin products and other insulins, particularly rapid-acting insulins, have been reported. Important Limitations of Use.
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Intravenous rapid-acting or short-acting insulin is the preferred treatment for this condition. Insulin regimens should be modified cautiously and only under medical supervision.
Changes in insulin strength, manufacturer, type, or method of administration may result in the need for a change in the insulin dose or an adjustment of concomitant anti-diabetic treatment. Do not administer subcutaneously via an insulin pump, intramuscularly, or intravenously because severe hypoglycemia can occur. Hypoglycemia is the most common adverse effect of insulin therapy.
American Diabetes Association
The timing of hypoglycemia may reflect the time-action profile of the insulin formulation. Glucose monitoring is recommended for all patients with diabetes and is particularly important for patients using external pump infusion therapy. Malfunction of the insulin pump or insulin infusion set or insulin degradation can rapidly lead to hyperglycemia and ketoacidosis.
Patients using insulin infusion pump therapy must be trained to administer insulin by injection and have alternate insulin therapy available in case of pump failure.
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The proportions of rapid-acting and long-acting insulins are fixed and do not allow for basal versus prandial dose adjustments. Changes should be made cautiously under close medical supervision and the frequency of blood glucose monitoring should be increased. Glucose monitoring is recommended for all patients with diabetes.
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Increase monitoring with changes to: insulin dose, co-administered glucose lowering medications, meal pattern, physical activity; and in patients with hypoglycemia unawareness or renal or hepatic impairment. Adverse reactions observed with insulin therapy include hypoglycemia, allergic reactions, local injection site reactions, lipodystrophy, rash, and pruritus. Necrolytic Migratory Erythema NME , a skin rash, has been reported postmarketing following continuous glucagon infusion and resolved with discontinuation of the glucagon.
Should NME occur, consider whether the benefits of continuous glucagon infusion outweigh the risks. Nausea and vomiting may occur, especially with doses above 1 mg or with rapid injection. Glucagon does not cross the human placenta barrier. It is unknown whether drug is excreted in human milk, therefore caution should be exercised.
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Adding a progestin to estrogen therapy has been shown to reduce the risk of endometrial hyperplasia, which may be a precursor to endometrial cancer. Adequate diagnostic measures, including directed or random endometrial sampling when indicated, should be undertaken to rule out malignancy in postmenopausal women with undiagnosed persistent or recurring abnormal genital bleeding. Estrogens with or without progestins should not be used for the prevention of cardiovascular disease or dementia.
The WHI estrogen plus progestin substudy also reported increased risks of DVT, pulmonary embolism, stroke and myocardial infarction in postmenopausal women 50 to 79 years of age during 5.
The WHI estrogen plus progestin substudy also demonstrated an increased risk of invasive breast cancer. The WHIMS estrogen plus progestin ancillary study also reported an increased risk of developing probable dementia in postmenopausal women 65 years of age or older during 4 years of treatment with daily CE combined with MPA, relative to placebo. It is unknown whether these findings apply to younger postmenopausal women.
In the absence of comparable data, these risks should be assumed to be similar for other doses of CE with or without MPA, and other combinations and dosage forms of estrogens with or without progestins. Estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman.
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This is NOT insurance. The range of discounts for prescriptions provided under this prescription discount plan will vary depending on the prescription and where the prescription is purchased. You are fully responsible for paying for your prescriptions at the pharmacy at the time of service, but will be entitled to receive a discount from pharmacies in accordance with the specific pre-negotiated discounted fee schedule.
Depending on the brand, this is about units of insulin. The press release suggests that this amount will cover the monthly needs of most people with diabetes. There is no limit to the number of cards people may use in a given timeframe. These insulins will be sold for half the cost of the current branded versions.